Kitasamycin A3

Kitasamycin A3 - General Information

A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. [PubChem]

Pharmacology of Kitasamycin A3

Kitasamycin A3 is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Additional information about Kitasamycin A3

Kitasamycin A3 Indication: For the treatment of bacterial infections.
Mechanism Of Action: The mechanism of action of macrolides such as Kitasamycin A3 is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Josamycin
Synonyms: Leucomycin A3; JM; Antibiotic yl-704 A3; Josamicina [inn-spanish]; Josamycine [inn-french]; Josamycinum [inn-latin]; Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate); Leucomycin V, 3-acetate 4(sup beta)-(3-methylbutanoate); Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
Drug Category: Antibacterial Agents; Macrolides
Drug Type: Small Molecule; Approved

Other Brand Names containing Josamycin: Josacine; Kitasamycin A3; Turimycin A5;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Kitasamycin A3: Not Available
Chemical IUPAC Name: [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-dimethylamino-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate
Chemical Formula: C42H69NO15
Josamycin on Wikipedia: https://en.wikipedia.org/wiki/Josamycin
Organisms Affected: Enteric bacteria and other eubacteria